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Diosmin API
Dedicated vascular and capillary protection formulas.
Custom Protection of blood vessels - Diosmin Company, Manufacturers | HawkDiosmin + Hesperidin 90/10
Synergistic mixture for enhanced venous circulation support.
Custom Diosmin+Hesperidin (mixture) 90/10 Company, Manufacturers | HawkMPFF
Micronized Purified Flavonoid Fraction for maximum bioavailability.
Custom Micronized Purified flavonoid Fraction (MPFF) Company, Manufacturers | HawkTarget Pharmaceutical Applications
Diosmin and flavonoid mixtures serve as foundational elements in vascular medicine, providing critical therapeutic support for complex circulatory pathologies.
Chronic Venous Insufficiency (CVI)
Diosmin targets the microcirculatory system to reduce capillary permeability and prevent venous stasis. Formulations containing Diosmin significantly alleviate the symptoms of CVI, including heavy legs, lower limb edema, nocturnal cramps, and persistent vascular tension.
Varicose Vein Formulations
By strengthening the venous wall structure and increasing venous tone (venotonic action), Diosmin helps slow down the progression of varicose veins. It reduces the inflammatory response of leukocytes on the endothelial lining, preventing structural degradation of the vein walls.
Hemorrhoid Formulations
In acute hemorrhoidal attacks and chronic hemorrhoidal management, fast-acting micronized flavonoid formulations provide rapid relief from pain, swelling, and bleeding. Diosmin works synergistically with other citrus flavonoids to stabilize capillary membranes and reduce local inflammation.
Mechanisms of Action in Venous Circulation
Diosmin acts as a highly effective venotonic agent by prolonging the vasoconstrictor effect of noradrenaline on the venous wall. This increases venous tone and reduces venous capacitance, distensibility, and stasis. At the microcirculatory level, it decreases capillary hyperpermeability and reinforces capillary resistance, protecting the blood vessels from inflammatory cascades.
Clinical studies show that the integration of Micronized Purified Flavonoid Fraction (MPFF) significantly improves absorption rates. Micronization reduces the active particles to less than 2 microns, enhancing bioavailability and accelerating therapeutic onset for patients suffering from acute conditions.
Synergistic Flavonoid Formulations
The combination of Diosmin with Hesperidin, particularly in the optimized 90/10 ratio, demonstrates a superior therapeutic outcome compared to Diosmin alone. Hesperidin serves as the precursor and synergist, amplifying the anti-inflammatory and vascular-protective pathways. This biochemical synergy is key to modern clinical protocols for chronic venous insufficiency and lymphatic drainage disorders.
Key Active Ingredients Profile
Our pharmaceutical-grade flavonoid portfolio is manufactured under strict GMP controls to ensure consistency, high purity, and optimal particle size distribution.
- Diosmin API: High-purity venotonic agent for standard oral dosage forms.
- Diosmin + Hesperidin 90/10: Synergistic blend optimized for maximum vascular wall stabilization.
- Micronized Purified Flavonoid Fraction (MPFF): Ultra-fine particle technology for superior bioavailability and rapid systemic absorption.
- Natural Citrus Extraction: Sourced from premium raw materials to ensure natural origin bioflavonoid integrity.
*All ingredients comply with international pharmacopoeia standards (EP, USP) and undergo rigorous testing at our independent analysis center.
30+
Years of Historical Experience
10+
Global Sales Areas (Overseas)
1,000+
Tons Annual Output of Raw Materials
Raw Material Display & Product Portfolio
Explore our premium raw materials and discover customizable API options tailored to your specific formulation needs.
WE ARE WORLDWIDE - Quality System & Certifications
Strict GMP compliance, international registrations, and rigorous quality assurance systems ensure our active pharmaceutical ingredients meet the requirements of global markets.
Hawk Bio. has established a perfect quality management system and implements strict GMP management throughout the entire process from raw material production, inspection to sales. We have obtained Drug Manufacturing License, and have completed the registration of APIs in the CENTER FOR DRUG EVALUATION, NMPA, the import license of APIs issued by the Russian MOH, and completed the registration of APIs in Brazil ANVISA. And passed the Kosher certification, Halal certification, ISO9001:2015 quality management system certification. We are also the audit unit of Hesperidin international business standard. It is subject to the daily supervision of the National Medical Products Administration and is regularly audited by foreign clients.
HONORS AND INVENTION
Hawk Bio. has obtained dozens of national invention patents and utility model patents. It has won honorary titles such as "A-level Tax Credit Rating Certificate", "Safety Production Standardization Certificate", "Municipal Key Leading Enterprise", "National High-tech Enterprise", "Municipal Technology Center", etc.
SUSTAINABILITY OF ENTERPRISE
The innovation progress of Hawk Bio. is pushing us towards a more sustainable future. We are actively responding to the United Nations Sustainable Development Goals and Climate Action. By the end of June 2024, the plant had installed the first phase of solar photovoltaic panels with a power generation capacity of 200KW, which can meet 60% of the electricity demand of the whole factory. After the completion of the second phase of the project, solar power generation will meet all the electricity demand of the whole factory.
Our commitment to sustainability extends to green chemistry extraction methods, reducing waste, and minimizing our environmental impact while maintaining high-yield pharmaceutical outputs.
Green Manufacturing Goals
- Clean Energy: 100% solar power target upon completion of Phase 2.
- EcoVadis Bronze: Recognized international sustainability rating.
- Resource Optimization: Advanced recycling of solvents used during citrus extraction.
- Carbon Reduction: Actively cutting down baseline greenhouse gas emissions in raw material transportation and processing.
State-of-the-Art Production & Research Facilities
Explore our advanced GMP workshops, testing centers, and research laboratories where raw citrus extracts are transformed into high-purity pharmaceutical-grade APIs.
Workshop Display
Our Laboratory
Partner with a Global Leader in Bioflavonoids
With over 36 years of experience, we provide consistent supply, premium quality, and full regulatory compliance for your pharmaceutical formulation needs. Contact our expert team today to request samples or technical documentation.